Hans de Looper

Hans de Looper is a researcher in the Department of Hematology at Erasmus MC, focusing on molecular mechanisms underlying hematological disorders. His work primarily investigates GATA2 deficiency syndrome and related blood cell development abnormalities, with significant contributions to understanding myeloid dysplasia and hematopoietic transitions.

His research interests include:

• GATA2 deficiency and transcription factor dysfunction
• Myelodysplastic syndromes and bone marrow failure
• Endothelial-to-hematopoietic transition processes
• Severe congenital neutropenia (Kostmann Syndrome)
• Epigenetic regulation in blood disorders
• Hematopoietic stem cell biology

Dr. de Looper's recent publications demonstrate a cohesive research program examining how genetic mutations in transcription factors like GATA2 lead to hematological diseases. His work combines genetic, epigenetic, and cellular approaches, often utilizing zebrafish models as indicated by his research fingerprint.

His scientific contributions have been published in leading hematology journals including Blood Advances and British Journal of Haematology, with several papers receiving notable citations and attention in the research community.

Dr. de Looper maintains active collaborations with prominent researchers at Erasmus MC including Dr. I.P. Touw and Dr. E. de Pater, contributing to the institution's strong reputation in blood disorder research. His work has practical implications for understanding and potentially treating various genetic blood disorders.