Hans-Uwe Simon

Professor Hans-Uwe Simon serves as President of Brandenburg Medical School (MHB) and is a member of the Executive Board & Management. He joined MHB on September 1, 2021, bringing extensive experience in medical research and academic leadership. His academic credentials include the titles 'Prof. Dr. med. Dr. hc mult.', indicating his status as a medical doctor, professor, and recipient of multiple honorary doctorates.

Professor Simon's research focuses on immunology with particular expertise in neutrophil and eosinophil biology. His work investigates cellular mechanisms of immune responses, including neutrophil extracellular trap formation, mitochondrial DNA release in eosinophils, and the molecular regulation of cell death pathways. His research has significant implications for understanding inflammatory processes and antibacterial defense mechanisms.

His publication record spans from 1999 to 2018, with articles appearing in top-tier journals including Nature Communications, Nature Medicine, Nature Cell Biology, and the New England Journal of Medicine. These publications demonstrate consistent contributions to understanding immune cell function and cellular mechanisms of immunity.

Key Scientific Contributions:

• Discovery of OPA1-dependent glycolytic ATP production in neutrophil extracellular trap formation
• Identification of mitochondrial DNA release mechanisms in eosinophils for antibacterial defense
• Elucidation of calpain-mediated switching between autophagy and apoptosis pathways
• Characterization of death receptor signaling in neutrophil survival
• Investigation of abnormal T cell clones in eosinophilia

As President of Brandenburg Medical School, Professor Simon oversees academic programs and research initiatives at the institution. His leadership combines deep scientific expertise with administrative experience to advance medical education and research at MHB.