Hannes Neuweiler

Priv.-Doz. Dr. Hannes Neuweiler is a Lecturer and Group Leader at the Department of Biotechnology & Biophysics, University of Würzburg, Germany. His research spans protein engineering, biophysics, and super-resolution microscopy, focusing on molecular mechanisms in spider silk assembly and chaperone dynamics.

• Education: PhD in Physical Chemistry (University of Heidelberg, 1999-2002)
• Postdoctoral: University of Bielefeld (2004-2006), University of Heidelberg (2003-2004)
• Marie Curie Fellow: MRC Center for Protein Engineering, Cambridge (2006-2010)

Neuweiler’s research interests center on protein folding kinetics, structural transitions in silk proteins, and allosteric regulation of molecular chaperones like Hsp90. He employs advanced fluorescence techniques, including photoinduced electron transfer (PET) and fluorescence correlation spectroscopy, to study dynamic processes at single-molecule resolution.

His publication trends reveal expertise in: (1) spider silk protein self-assembly (methionine hydrophobic cores, domain swapping), (2) cysteine protease inhibition mechanisms (Rhodesain in parasitic pathogens), (3) chaperone ATPase dynamics (Hsp90 conformational coupling), and (4) precision immunotherapy (split antibody systems). Key subfields include biophysics of protein interactions, pH-dependent dimerization, and nanoscale fluorescence imaging.

At the University of Würzburg, Neuweiler leads a research group focused on protein engineering & dynamics, utilizing super-resolution microscopy (dSTORM, fluorescence correlation spectroscopy) to unravel molecular mechanisms in silk formation and chaperone function. His work bridges structural biology with applications in biomaterial design and therapeutic targeting.