Guy A. Caldwell

Dr. Guy A. Caldwell is a University Distinguished Research Professor in the Department of Biological Sciences at the University of Alabama. His research focuses on neurodegenerative diseases, particularly Parkinson’s, Alzheimer’s, and dystonia, using the model organism C. elegans. He holds a PhD in Cell and Molecular Biology from the University of Tennessee (1993) and completed postdoctoral training at Columbia University.

His laboratory investigates cellular mechanisms underlying neuronal dysfunction, leveraging C. elegans for genetic, genomic, and drug screening strategies. Key research areas include mitochondrial dynamics, protein aggregation, and environmental neurotoxicity. Funding sources include NIH, NSF, Howard Hughes Medical Institute, and industry partnerships. The lab has contributed to Nobel Prize-winning work through C. elegans research.

Dr. Caldwell advises graduate and undergraduate students, with alumni advancing to prestigious institutions like MIT, Harvard, and industry roles at Genentech and Pfizer. The lab’s website, caldwelllab.ua.edu, provides further details on ongoing projects and publications.