Guillaume F. Chanfreau

Guillaume F. Chanfreau serves as Professor of Biochemistry in the Department of Chemistry and Biochemistry at the University of California, Los Angeles, where his research integrates transcription and post-transcriptional mechanisms to elucidate eukaryotic gene regulation systems.

His academic credentials include:

• BS from University of Lyon & Ecole Normale Supérieure Lyon
• PhD from University of Paris VI
• Habilitation from University of Paris XI
• Human Frontier Science Program Postdoctoral Fellowship at University of California, San Francisco

Chanfreau's research centers on RNA biology and gene expression quality control, employing genome-wide approaches to investigate how cells eliminate aberrant RNA species generated during transcription and splicing. His laboratory has pioneered discoveries in RNA degradation pathways, ribosomal protein modification, and the coupling of metal homeostasis to transcriptional machinery, with significant implications for understanding cellular differentiation and disease pathologies.

Analysis of his recent publications (2012-2016) reveals consistent focus on RNA processing mechanisms in Saccharomyces cerevisiae, particularly splicing regulation, exonuclease-mediated degradation, and the functional consequences of protein methylation on translation fidelity and ribosome assembly. Key thematic threads connect RNA metabolism to cellular stress responses and metal ion homeostasis.

His scientific recognition includes:

• Human Frontier Science Program Postdoctoral Fellowship

Chanfreau has mentored over 15 PhD students including Charles Wang, Jason Gabunilas, and Tad Kawashima, alongside numerous postdoctoral researchers such as Cesar Fernandez and Isabelle Toesca. His laboratory has maintained consistent funding through competitive fellowships and likely NIH/NSF mechanisms supporting his systems biology approach to RNA research, though specific grant details remain unreported in available materials.

The Chanfreau laboratory operates as a collaborative research unit within UCLA's biochemistry department, utilizing yeast genetics, genomic techniques, and structural approaches to dissect fundamental mechanisms of gene expression regulation across cellular conditions.