Guillaume Dorothée

Guillaume Dorothée is a Researcher at Inserm, affiliated with Sorbonne University. His work focuses on translational neuroimmunology, bridging innate and adaptive immunity in neurodegenerative and neurological diseases. He leads the Neuroimmunology, Inflammation and Therapeutics team based at Saint-Antoine Hospital, Kourilsky Building, 3rd floor.

• University: Sorbonne University
• Research Affiliation: Inserm
• Contact: guillaume.dorothee@inserm.fr

Dr. Dorothée's research program includes four thematic areas (WP1-WP4) addressing:

• T cell interactions with innate neuroinflammation in Alzheimer’s and tauopathies
• Early neuroinflammatory impacts on neuronal function
• Neutrophil roles in Alzheimer’s, stroke, and epilepsy
• Serological biomarkers for cerebral amyloid angiopathy

His team collaborates with clinical services at Sainte-Anne Hospital, CEA, and Saint-Antoine Hospital, integrating preclinical mouse models with clinical data. Key methodologies include multiparametric serological analyses and neuroimaging.

The students under his mentorship include Inés El Haddad, Alexander Glastra, Manon Graffeuil (CIFRE PhD), Julie Marsande, Amber Pouveau, and Coraly Simoes.