Guido J. Falcone

Guido J. Falcone, MD, ScD, MPH is an Associate Professor of Neurology at Yale School of Medicine, where he serves as Academic Chief of the Division of Neurocritical Care, Director of Clinical Research in Neurocritical Care, and Training Director of the Yale/AHA Bugher Center for Intracerebral Hemorrhage Research. As a Neurointensivist, he specializes in treating critically ill patients with neurological injuries including stroke, hemorrhage, traumatic brain injury, and seizures.

Dr. Falcone's educational background includes an MD from the University of Buenos Aires School of Medicine, a Neurology Residency at F.L.E.N.I., an MPH in Quantitative Methods from Harvard School of Public Health, an ScD in Epidemiology from Harvard School of Public Health, and a Neurocritical Care Fellowship at Harvard Medical School/Massachusetts General Hospital/Brigham and Women's Hospital.

His research program bridges clinical neurology, neuroimaging, population genetics, and genomic medicine to understand how genetic variation influences stroke occurrence, severity, and outcomes. He employs genetic approaches to identify novel biological mechanisms, answer epidemiological questions, and develop precision medicine tools for risk stratification. Dr. Falcone maintains an active research program within the International Stroke Genetics Consortium, collaborating with investigators worldwide.

An analysis of Dr. Falcone's most recent publications reveals a strong focus on stroke genetics, particularly examining how polygenic risk factors influence intracerebral hemorrhage, response to blood pressure management, and vascular risk factor control in stroke survivors. His work increasingly integrates multiple 'omics' approaches (genomics, proteomics, transcriptomics) to identify therapeutic targets for cerebrovascular disease and related conditions.

• Yale Office for Postdoctoral Affairs' Annual Mentorship Award (2024)
• Paul Dudley White International Scholar Award (2022)
• Michael S. Pessin Stroke Leadership Prize (2021)
• Get With The Guidelines (Stroke) Early Career Investigator Award (2020)
• American Society of Clinical Investigation Young Physician-Scientist Award (2020)

Dr. Falcone serves as Principal Investigator for the ASPIRE trial (Anticoagulation for Stroke Prevention and Recovery After ICH) and is a Sub Investigator for multiple other clinical trials including BEACH, REDUCE, and BOOST3. He has secured significant grant funding through the American Heart Association and other organizations to support his research in stroke genetics and neurocritical care. His mentorship has been recognized with Yale's Postdoctoral Affairs Annual Mentorship Award, reflecting his commitment to training the next generation of physician-scientists.

Dr. Falcone leads the Falcone Lab at Yale, which focuses on integrating genetic, neuroimaging, and outcomes data to identify novel therapeutic targets and precision medicine strategies for stroke and aging-related conditions. His team employs multidisciplinary approaches to understand how common and rare genetic variation influences stroke risk, severity, and recovery trajectories.