معرفی
Guang Yao is an Associate Professor at the University of Arizona, holding joint appointments in the Department of Molecular & Cellular Biology, Cancer Biology Graduate Interdisciplinary Program (GIDP), Genetics GIDP, and Applied Mathematics GIDP. His research focuses on cellular quiescence, cancer mechanisms, and systems biology, integrating experimental and computational approaches. Yao leads a lab based in Life Sciences South, Rooms 515 & 519, with expertise spanning molecular biology, bioinformatics, and interdisciplinary collaborations. His work explores cellular dormancy dynamics, cancer dormancy, and translational applications in therapy resistance.
Research interests include understanding how cellular states transition between proliferation, quiescence, and senescence, with emphasis on signaling pathways (e.g., Rb-E2F networks), circadian regulation, and drug modulation. Yao’s lab investigates biomarkers for ovarian cancer and viral pathogenesis (e.g., DHAV-3), while applying machine learning to predict disease outcomes and drug responses.
Key findings bridge basic science and clinical applications, such as identifying miR-449’s role in ovarian cancer mitigation and phospholipase A2’s involvement in severe COVID-19 pathogenesis. His articles highlight novel methods for quantifying quiescence depth and modeling cellular state transitions.
