Gregory Holmes-Hampton

Gregory Holmes-Hampton, Ph.D., is a Professor in the Department of Pharmacology & Molecular Therapeutics at the Uniformed Services University of the Health Sciences (USUHS) in Bethesda, MD. He holds a primary appointment in the School of Medicine and focuses on radiation biology, radiobiology, and medical countermeasures against radiation-induced injuries.

His education includes a B.S. in Chemistry from Illinois State University, a Ph.D. in Chemistry from Texas A&M University, and postdoctoral training at the National Institutes of Health (NICHD/NIH). His research emphasizes radiation effects on biological systems, including IGF-1 signaling pathways, antioxidant responses, and mitochondrial degeneration. He also investigates novel countermeasures for acute radiation syndrome (ARS), such as CDX-301 and manganese chloride, and explores sex-based differences in radiation responses.

Key research trends in his articles include multi-organ radiation injury modeling, microbiome-inflammasome interactions, and the role of miRNA in radiation toxicity. His work spans preclinical studies in murine and minipig models, with a focus on translational applications for military and civilian radiation emergencies.

Notable collaborations include the Armed Forces Radiobiology Research Institute and interdisciplinary teams studying heme biosynthesis and iron metabolism. His lab’s activities prioritize radiation countermeasure development and understanding late health effects of partial-body irradiation.