Gregory C Rogers

Gregory C. Rogers is a Professor in the Department of Cellular and Molecular Medicine at the University of Arizona College of Medicine. He has been affiliated with the university since 2014 and leads the Rogers Lab, which focuses on centriole duplication regulation and interphase chromatin organization. His research bridges cell biology and cancer biology, with a focus on mechanisms linking centrosome dysfunction to genomic instability and cancer progression.

Rogers holds a Ph.D. in Cellular Biology from the University of California, Davis (2000), where his thesis explored microtubule motor coordination in sea urchin embryogenesis. His work has expanded into prostate cancer mechanisms, centrosome biology, and the role of Polo-like kinase 4 (Plk4) in centriole assembly. Key collaborations include Gio Bosco (Dartmouth) for chromatin studies and studies on progeria variants in Drosophila.

Research interests include: (1) Regulation of centriole duplication to prevent aneuploidy and cancer, (2) Chromatin compaction dynamics during interphase, and (3) Centrosome loss mechanisms in prostate carcinogenesis. His lab develops CRISPR-based tools for studying centriole assembly in Drosophila S2 cells.

Recent work highlights hypoxia-induced centrosome loss as a driver of chromosomal instability in prostate cancer and identifies therapeutic targets like PIM kinases. The lab also investigates Plk4’s phosphorylation-driven regulation and structural roles in centriole growth through distal tip complex interactions.

No formal awards are listed, though his extensive publication record reflects recognition in the field. Teaching responsibilities include courses like Cancer Biology (CBIO 552) and Principles of Cell Biology (MCB 577). His work integrates molecular genetics, live-cell imaging, and computational analysis to advance understanding of centrosome dysfunction in disease.