Greg A. Snyder

Greg A. Snyder, PhD, is an Assistant Professor at the University of Maryland School of Medicine, with primary appointments in the Department of Medicine and secondary appointments in Microbiology and Immunology. He works in the Division of Infectious Agents and Cancer at the Institute of Human Virology, focusing on structural immunobiology and molecular mechanisms of immune signaling.

• Education: B.S. in Chemistry from Creighton University, Ph.D. in Structural Immunology from Northwestern University.

Dr. Snyder's research centers on Toll-like and Interleukin-1 receptor signaling pathways, host-microbe interactions, and microbial immune evasion strategies. His work explores structural characterization of TIR domains, bacterial protein mimicry, and modulation of inflammatory responses in diseases like cancer and infections.

Recent publications highlight structural studies of bacterial/viral TIR proteins (Brucella, Escherichia coli), tick-derived inflammasome inhibitors, and Toll-like receptor antagonists. These studies span immunology, structural biology, and microbiology, with implications for vaccine design and inflammatory disease therapies.

His laboratory investigates molecular recognition in innate immunity, including DC-SIGN/gp120 interactions (HIV-1), NLRC4 inflammasome inhibition by sialostatin L2, and structural mechanisms of TLR signaling disruption by pathogens.