معرفی
Graeme F. Mason is a Professor of Radiology & Biomedical Imaging (Primary) and Psychiatry (Secondary) at Yale University School of Medicine. He serves as Director of Metabolic Modeling and Director of Psychiatric MRS at the Magnetic Resonance Research Center, Director of the Neuroimaging Sciences Training Program, and Chair of the Magnetic Resonance Research Center Protocol Review Committee. His work integrates quantitative approaches to measure functional brain chemistry and study diabetes, metabolic syndrome, and neuropsychiatric disorders.
Dr. Mason's research focuses on brain metabolism and neurotransmission using 1H and 13C Nuclear Magnetic Resonance (NMR) and Mass Spectrometry with 13C isotopic labeling. His primary areas of interest include the effects of alcohol on the brain from perspectives of neurotransmission, metabolism, adaptation, and vulnerability to dependence. He also studies depression, alcoholism, and post-traumatic stress disorder, with particular interest in relationships among GABA, glutamate, and glutamine concentrations and their synthesis and release rates in the brain.
His recent publications demonstrate a strong focus on metabolic brain imaging, particularly examining brain glucose transport, neurotransmitter metabolism, and the effects of metabolic conditions like obesity and hyperglycemia. His work combines advanced imaging techniques with mathematical modeling to understand brain energy metabolism and its alterations in various conditions. The research spans from basic metabolic studies to clinical applications in psychiatric and metabolic disorders.
- Neuropsychopharmacology Top 10 Reviewers (2022)
- Editor's Recognition for Reviewing, Biological Psychiatry (2020)
- Inducted into the Academy Distinguished Investigator Council (2018)
- Editor's Recognition for Reviewing, Biological Psychiatry (2016)
- Elected Fellow, American College of Neuropsychopharmacology (2015)
Dr. Mason collaborates extensively with researchers across Yale, particularly with Kevin Behar, Douglas Rothman, John Krystal, Robin de Graaf, and Janice Jin Hwang. He serves as a sub-investigator on multiple clinical trials examining brain metabolism in conditions including diabetes, psychiatric disorders, and OCD. His work is supported by various NIH-funded projects and institutional resources.
As Director of the Neuroimaging Sciences Training Program in Substance Abuse and key figure in the Magnetic Resonance Research Center, Dr. Mason leads a team developing advanced MR techniques for brain metabolism studies. He has developed specialized software like CWave for analyzing 13C isotopic labeling in brain studies, which is used to measure metabolic rates and track substrate consumption in the brain.
