معرفی
Godelieve Moons serves as a full Professor in the Department of Biology at the Faculty of Sciences, KU Leuven. She leads research within the Animal Physiology and Neurobiology unit and holds key affiliations with the KU Leuven Brain Institute (LBI), KU Leuven Institute for Rare Diseases (Leuven.IRD), and KU Leuven Institute for Single Cell Omics (LISCO). Her institutional roles include membership in the Faculty Council of Sciences, Departmental Council of Biology, and specialized Program and Oversight Committees (POCs) for Biochemistry, Biotechnology, and Sexological Sciences.
Her research centers on neurobiological mechanisms of aging and regeneration, with particular focus on glial cell dynamics, myelin integrity, and axonal repair. Using the rapidly aging African turquoise killifish as a primary model, she investigates how intraneuronal energy redistribution drives functional recovery in the central nervous system, explores non-mitochondrial metabolic pathways for axon regrowth, and examines age-related glial changes impacting remyelination. Her work bridges fundamental neurobiology with therapeutic development for neurodegenerative conditions and healthy brain aging.
Analysis of her 2025 publications reveals a cohesive research trajectory centered on killifish models to decode aging-related neural decline. Key thematic clusters include oligodendroglial heterogeneity in myelin dynamics, metabolic reprogramming for neural repair, and the interplay between mitochondrial function and regeneration capacity. Her studies consistently integrate single-cell omics, in vivo genome editing, and functional recovery metrics to identify therapeutic targets for conditions like Wolfram syndrome and age-related neurodegeneration.
Professor Moons actively supervises doctoral candidates including Faneca Santos, J. and Marien, V., while leading multiple major research initiatives. She currently serves as Promotor for six projects and Co-promotor for four others, including "Herverdeling van intraneuronale energie stuurt functioneel herstel" (2022-2026), "Onderzoek naar leeftijdsgerelateerde gliale veranderingen" (2022-2028), and "Gezond ouder worden met behulp van waardevolle lignine-derivaten" (2024-2027), collectively securing substantial funding for neural regeneration research.
Her laboratory operates within KU Leuven's BioScience Center infrastructure, utilizing advanced platforms including killifish R&D systems for drug screening, stem cell-derived optic nerve-on-chip models, and in vivo genome editing techniques. The team collaborates extensively through the LBI and Leuven.IRD networks to translate findings into therapeutic strategies for neurodegenerative diseases and healthy aging interventions.