Giles E. Duffield

Giles E. Duffield is an Associate Professor in the Department of Biological Sciences at the University of Notre Dame, College of Science. His research focuses on the molecular mechanisms of circadian rhythms in both mammals and mosquito vectors, with implications for human health, metabolic disorders, and vector-borne disease control.

Research Interests: Dr. Duffield’s work investigates the molecular basis of circadian clocks, particularly the role of Inhibitor of DNA binding (Id2, Id4) genes in regulating the mammalian circadian system and metabolic homeostasis. His lab studies circadian control of metabolism, photic entrainment, and the genomic regulation of rhythmic gene expression in the malaria vector Anopheles gambiae. His interdisciplinary approach integrates molecular biology, genomics, behavioral analysis, and proteomics.

Recent Research Trends: His recent publications highlight a strong focus on circadian regulation in disease vectors, including how artificial light alters mosquito biting behavior and how circadian clocks influence insecticide resistance. In mammalian systems, his work explores the intersection of circadian disruption with metabolic diseases such as obesity, diabetes, and alcoholic liver disease. His research also contributes to methodological advances in circadian genomics.

• Scientific Awards and Grants:

• Indiana CTSI Fall Core Pilot Grant (2011)
• Supported by NIGMS, American Heart Association, Indiana CTSI, Eck Institute for Global Health, and Center for Rare and Neglected Diseases
• Previously funded by Royal Society and Wellcome Trust

Advising and Grants: Dr. Duffield has mentored numerous graduate and undergraduate students, many of whom have pursued advanced degrees in medicine and science. His lab has secured significant external funding, enabling cutting-edge research in circadian biology and vector control. Collaborations span institutions including Indiana University, Dartmouth, Oxford, and the University of Washington.

Labs and Teams: The Duffield Lab at Notre Dame employs transgenic mouse models, real-time bioluminescence imaging, transcriptomics, and behavioral assays to study circadian function. The team includes postdoctoral researchers, graduate students, and undergraduates, and maintains active collaborations with experts in proteomics, metabolism, and vector biology.