Georgiadis Dimitris

Professor Georgiadis Dimitris is a faculty member at the Department of Chemistry, National and Kapodistrian University of Athens. He specializes in Organic Chemistry with a focus on enzymology, peptide chemistry, and drug design. His research emphasizes developing inhibitors for zinc-metalloproteases and aminopeptidases, particularly targeting cancer-associated proteases and immunological pathways. Key areas include antigen processing mechanisms, MMP inhibition for cancer imaging, and synthetic strategies for phosphinic peptides. His work bridges organic chemistry and biomedical applications, aiming to advance cancer therapeutics and immunology.

Research Focus: His studies explore enzyme-inhibitor interactions, structural biology of proteases, and applications in cancer and immune system modulation. He has pioneered methods for designing selective inhibitors of ERAP1/2 and MMPs, contributing to understanding antigen presentation pathways and their role in autoimmune diseases and malignancies.

Publications Overview: Recent work highlights advancements in covalent protease labeling, first-in-class HYOU1 inhibitors, and structural insights into ERAP1 dynamics. These studies underscore his team's expertise in linking molecular mechanisms to translational medicine.

Grants & Labs: While specific grants/labs are not detailed here, his extensive publication record indicates sustained involvement in collaborative research projects funded by biomedical initiatives. His lab likely focuses on chemical biology, enzymology, and drug development.