George R. Uhl

George R. Uhl is Professor of Neurology and Pharmacology at the University of Maryland School of Medicine, serving as Chief of Neurology and Associate Chief of Staff for Research at the VA Maryland Healthcare System. Previously held academic positions at Johns Hopkins University, Harvard Medical School, and NIH/NIDA.

His educational background includes:

• BA: Johns Hopkins University
• PhD: Johns Hopkins School of Medicine
• MD: Johns Hopkins School of Medicine
• Internal Medicine: Stanford University Hospitals
• Neurology: Johns Hopkins Hospital

Dr. Uhl's research spans neurology, neuropharmacology, and molecular neurobiology with emphasis on Parkinson's disease, Alzheimer's disease, pain, restless leg syndrome, and addiction. His work integrates complex genetics with therapeutic development, focusing on post-GWAS gene discovery and molecular mechanisms of neurodegeneration.

Recent publications reveal consistent themes in molecular targets for neurodegenerative disorders and addiction, particularly PTPRD phosphatase modulation, dopamine compartmentalization in Parkinson's, and genetic vulnerabilities in polysubstance abuse. These studies demonstrate translational pathways from gene discovery to therapeutic candidates.

Scientific recognition includes:

• Fellow of the American Neurological Association
• Fellow of the American College of Neuropsychopharmacology
• Scientific Advisory Board Member, RLS Foundation

Dr. Uhl has authored 165+ peer-reviewed papers and 125+ reviews (H-index >115), founded a journal, and holds intellectual property for PTPRD inhibitors and flavonol analogs. Research funded by NIDA and NIA focuses on developing phosphatase inhibitors for addiction/obesity and Alzheimer's therapeutics. His laboratory leads post-GWAS validation studies and molecular drug development pipelines.