معرفی
George R. Dubyak, PhD, is a Professor in the Departments of Physiology and Biophysics, Pathology, and Pharmacology at Case Western Reserve University's School of Medicine. He is also a Member of the Immune Oncology Program at the Case Comprehensive Cancer Center. His research focuses on cell signaling mechanisms involving inflammasomes, ion channels, and extracellular nucleotides in inflammation and innate immunity.
Dr. Dubyak holds a PhD in Physiology from the University of Pennsylvania. His work explores ATP signaling via P2 receptors, inflammasome activation pathways, and mechanisms of IL-1β secretion. Recent studies investigate regulated cell death pathways (pyroptosis, apoptosis, necroptosis) and ATP efflux from tumor cells. The Dubyak Lab utilizes murine models and advanced cellular techniques to dissect these processes.
Key research areas include: inflammasome assembly regulated by ionic signals, non-classical cytokine secretion via exosomes/microvesicles, and DAMP signaling in inflammation and cancer. Dr. Dubyak has published extensively in journals like Journal of Biological Chemistry and Journal of Immunology.
His lab is located in the Robbins Building (E-550 G, H, I, J) with state-of-the-art facilities for cellular and molecular biology. Current projects examine cross-talk between P2 nucleotide signaling and inflammasomes, as well as mechanisms governing extracellular ATP accumulation in disease contexts.
