George J. Feldman

George J. Feldman, PhD, DMD, is a Research Assistant Professor at the College of Life Sciences, based at 1015 Walnut Street, Curtis Building, Room 501, Philadelphia, PA 19107. He can be contacted via phone at 215-955-5480.

His research focuses on identifying genetic causes of inherited orthopaedic disorders, with particular emphasis on Developmental Dysplasia of the Hip (DDH). His lab investigates how incomplete hip socket formation leads to dislocation and osteoarthritis, utilizing two primary approaches:

• Traditional linkage analysis of affected families using Affymetrix SNP platforms
• Examination of copy number variations in severely affected individuals with bilateral DDH

The goal is to develop genetic tests enabling early intervention (e.g., Pavlik harness) to prevent osteoarthritis progression.

His publications center on genetic mechanisms underlying orthopaedic conditions including fibrodysplasia ossificans progressiva (FOP), BMP pathway mutations, and skeletal malformation syndromes. Research demonstrates consistent focus on mutation discovery in bone-forming pathways.