George Hajishengallis

George Hajishengallis is a Professor at the Department of Microbiology, Penn Dental Medicine, University of Pennsylvania. His research focuses on the immunological mechanisms underlying periodontal disease, trained immunity, and inflammatory comorbidities, with particular emphasis on complement biology, neutrophil function, and host-pathogen interactions in oral microbial communities.

• Key Research Areas: Complement system, DEL-1 protein, trained immunity, innate immune memory, periodontitis, inflammatory bone loss, cross-organ comorbidities.
• Recent Work: Investigates DEL-1's role in bone regeneration, complement inhibition therapies, and trained immunity's impact on cardiometabolic and autoimmune diseases.
• Collaborations: Engages in cross-disciplinary studies linking oral inflammation to systemic conditions like hypertension and atherosclerosis.

His publications highlight innovative approaches to modulating inflammation via metabolic reprogramming, integrin signaling, and complement-targeted therapies. Clinical trials (e.g., C3 inhibitor AMY-101) and preclinical models (e.g., mouse periodontitis) are central to his translational research.