Geneviève Derumeaux

Geneviève Derumeaux is a Lecturer-Researcher and Team Leader at the SENescence, Vulnerability, and ChrOnic DisEases (SENCODE) team within the Mondor Institute of Biomedical Research (IMRB), affiliated with the Faculty of Health of Créteil. Her work focuses on cellular senescence mechanisms in chronic lung and cardiovascular diseases, particularly pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD). She leads a multidisciplinary team investigating senescence's role in vascular remodeling and tissue degeneration, with translational goals to develop novel therapies targeting senescence pathways. Key achievements include pioneering the link between COPD and systemic accelerated aging, securing patents, and co-founding the DHU (University-Hospital Department) on age-related diseases.

Research Interests: Her team explores senescence in PH, COPD, and cardiovascular disorders, integrating molecular, cellular, and clinical approaches. They study telomere dysfunction, p53 activation, CCR5 signaling, and senolytic therapies. Collaborations extend to cardiology and epidemiology, leveraging patient cohorts for phenotypic aging analysis.

Career & Collaborations: Prof. Derumeaux co-coordinates the DHU on age-related diseases and has attracted senior researchers like T. Damy and G. Derumeaux. Her lab employs advanced techniques (e.g., flow cytometry, mass spectrometry) and maintains close ties with clinical teams for translational impact. Recent advances include resolvin E1's role in ciliary dyskinesia and lipid metabolic switches in senescence.

Affiliations: IMRB (Inserm U955), Mondor Hospital, and the Faculty of Health of Créteil. Active in national/international networks on aging and respiratory diseases.