Gene Hart-Smith

Dr. Gene Hart-Smith is a Technology Manager for Protein Interactions at the Australian Proteome Analysis Facility (APAF), affiliated with Macquarie University. He holds a PhD in Chemistry from the University of New South Wales (UNSW) and has extensive postdoctoral experience, including ARC-funded fellowships (2011–2018). His expertise lies in mass spectrometry applications for biological systems, particularly protein interactions and post-translational modifications.

Education:

• PhD in Chemistry, UNSW (2006–2010)
• Bachelor of Engineering (Industrial Chemistry, Honours Class 1), UNSW (2001–2005)

Research Focus: Hart-Smith’s work integrates molecular systems biology and network theory to study biomolecular interaction networks. Key areas include protein modifications (e.g., arginine methylation), X chromosome inactivation in marsupials, and applications to diseases like Alzheimer’s. He develops proteomics methodologies for environmental and medical research, such as root architecture studies in rice and concussion biomarker identification in children.

Recent Research Trends: His articles (2024–2021) highlight advancements in protein interactome mapping, drug discovery, and biomarker development. Techniques like mass spectrometry, ion mobility, and co-fractionation are central to his methodologies.

Awards:

• ARC DECRA Fellowship (2015–2018)
• ARC Australian Postdoctoral Fellowship (2011–2014)

Collaborations: Hart-Smith collaborates globally on projects ranging from archaeological bone analysis to cancer therapy development. His work bridges fundamental research and applied solutions in sustainability and healthcare.