Ge Guo

Dr. Ge Guo is a leading researcher at the University of Exeter within the Living Systems Institute. Their work focuses on human naïve pluripotent stem cells and cell fate transitions during early embryo development, with a particular emphasis on developmental plasticity and synthetic embryo modeling.

Key research areas include:

• Characterizing human naïve pluripotency and its unique potential to differentiate into embryonic and extraembryonic lineages.
• Developing synthetic human blastocyst models to study early embryo development using molecular, genetic, and biophysical approaches.
• Comparative analysis of pluripotent stem cells across mammalian species.

Their recent breakthrough in generating human blastoids (synthetic embryos) has opened new avenues for research in reproductive medicine and developmental biology. Current projects include:

• Elucidating gene regulatory mechanisms in naïve stem cells.
• Investigating epigenetic resetting processes.
• Developing advanced in vitro embryo models.

Research outputs span stem cell biology, genetics, and computational biology, with a focus on human-specific developmental features. The lab actively recruits postdocs and PhD students for these cutting-edge projects.