Gaspard HUBER

Gaspard Huber is a Researcher at the French Alternative Energies and Atomic Energy Commission (CEA), working within the IRAMIS institute, NIMBE unit, and LSDRM laboratory (Laboratory of Structure and Dynamics by Magnetic Resonance) since 2002. His research focuses on hyperpolarization techniques to overcome NMR's sensitivity limitations, with applications spanning metabolomics, biosensors, and materials science.

His educational background includes:

• Chemical Engineering degree from ESCIL (now CPE Lyon), 1993
• PhD from CEA Grenoble (1996, supervised by Dr. Jacques Gaillard)
• Habilitation to lead research (2006)
• Post-doctoral positions at University of Florence (1996-1998) and BIP-CNRS Marseille (1998-1999)

Huber's research centers on hyperpolarization methodologies using parahydrogen and laser-polarized noble gases, enabling breakthroughs in metabolomic profiling of microscopic specimens and xenon-based biosensors. Current projects include ANR-funded SOFTNMR (flow NMR techniques) and HELPING (noble gas polarization), supporting active PhD and post-doctoral recruitment. His work bridges fundamental NMR physics with biomedical applications through supramolecular host-guest chemistry.

Publication trends since 2013 reveal three interconnected domains: 1) Hyperpolarization engineering (SABRE/PHIP techniques for signal enhancement), 2) Supramolecular biosensors (cryptophanes/cucurbiturils for xenon detection), and 3) Metabolomic applications using HR-μMAS NMR. Key innovations include oxygen-carrying cucurbituril derivatives and single-scan diffusion-ordered NMR for hyperpolarized mixtures.

He actively supervises students, with a new PhD fellow starting October 2024, and collaborates internationally through the HELPING project with laboratoire Kastler Brossel. His LSDRM laboratory provides specialized infrastructure for magnetic resonance research in materials and biomedicine.

Notable patents include:

• 'Cucurbituril derivatives as oxygen carriers' (2017)
• NMR-based rubber characterization methods (2001)
• Reactor-NMR coupling devices (2000)
• Living cell analysis via NMR (2000)