Ganjam V. Kalpana

Ganjam V. Kalpana is a Professor in the Department of Genetics and holds a joint appointment in the Department of Microbiology & Immunology at Albert Einstein College of Medicine. She is the Mark Trauner Faculty Scholar in Neuro-oncology. Her research focuses on understanding the role of INI1/hSNF5/SMARCB1 in HIV-1 replication and cancer, particularly investigating its role in chromatin remodeling, tumor suppression, and viral integration. She develops novel therapeutic strategies targeting these pathways.

Her research interests include molecular genetic analysis of INI1 in HIV latency, cancer biology, and the interplay between viral and cellular transcription. She pioneered the SMIRA assay—a single-cell, single-molecule technique—to study latent HIV reservoirs in collaboration with Dr. Robert Singer. Additionally, her work on INI1's RNA-binding capabilities and its implications for transcriptional regulation bridges viral and cellular biology.

Her publications highlight advancements in antiviral therapies, tumor suppression mechanisms, and molecular oncology. Collaborations with international teams have led to discoveries about INI1's nuclear export pathways and their therapeutic potential in cancer. Her contributions span from basic molecular mechanisms to translational clinical applications.

Awards and recognitions are not explicitly listed in the provided text.

Dr. Kalpana’s lab focuses on translating fundamental discoveries into clinical solutions, including targeting INI1 pathways in cancers and developing RNA-based HIV inhibitors. She maintains active grants and collaborations, though specific grant details are not provided here.

Her laboratory is part of the Jack and Pearl Resnick Campus, collaborating extensively in virology and cancer research. Future work emphasizes clinical translation of anti-HIV therapeutics and precision therapies for INI1-deficient tumors.