معرفی
Gabriele Floris is an Associate Research Scientist in the Department of Psychiatry at Yale University. His primary research focuses on neuropharmacology, addiction biology, and translational neuroscience with particular emphasis on mechanisms underlying drug-seeking behavior, neuroinflammation, and neuropsychopharmacological interventions. Dr. Floris uses rodent models to investigate how substances like heroin, psilocybin, and cannabis influence neural circuits involved in reward processing, stress responses, and decision-making.
Key research areas include: 1) Neurosteroid modulation of addiction pathways, 2) Circular RNA and microRNA regulatory mechanisms in addiction, 3) Neuroimmune interactions in substance use disorders. His work bridges basic science and clinical applications, aiming to identify novel therapeutic targets for opioid use disorder and related neuropsychiatric conditions.
Recent studies have explored the efficacy of psilocybin in reducing heroin relapse and the role of 5α-reductase inhibitors in modifying drug-seeking behavior. He has developed innovative behavioral paradigms like the sinking platform test to measure persistence in animal models. Collaborations with Mary Zanda and Stephen Daws highlight his network in translational addiction research.
