G. Mugesh

Professor G. Mugesh holds the Department of Inorganic and Physical Chemistry at the Indian Institute of Science, Bangalore. His research bridges chemical biology, bioinorganic chemistry, and medicinal chemistry to address biomedical challenges through redox regulation and nanomaterial engineering.

• Recipient of J. C. Bose National Fellowship (Second Term) and Swarnajayanti Fellowship
• Developed nanozymes for glutathione peroxidase, superoxide dismutase, and catalase mimicry

Research focuses on thyroid hormone metabolism, reactive oxygen species detection, and ferroptosis regulation, with recent work on genetic code expansion for enhanced protein delivery. His iodine-substituted fluorescent probes revealed novel halogen bonding mechanisms in cell membrane transport.

Key findings include:

• First chemical model for inner-ring deiodination of thyroxine
• Discovery of crystal facet-dependent catalytic activity in manganese oxide nanozymes
• Development of vanadia nanowires that modulate signaling pathways in pulmonary embolism models

His group has received multiple grants from DST, DBT, and CSIR, with international collaborations like those with Hadassah Medical Organization. The team has established multidisciplinary laboratories for organic/inorganic synthesis and cell-based studies.