Frederik Tibert Larsen

Frederik Tibert Larsen is a researcher at the Department of Biochemistry and Molecular Biology, University of Southern Denmark, and a member of the ATLAS - Center for Functional Genomic Studies of Tissue Plasticity. His work focuses on liver disease, biomarker development, and functional genomics, with a particular emphasis on metabolic dysfunction-associated steatotic liver disease (MASLD) and non-alcoholic steatohepatitis (NASH).

• Key Research Areas: Liver disease, cell-cell interactions, functional genomics, and biomarker validation.
• Methodologies: Utilizes precision-cut liver slices, single-cell transcriptomics, and proteomic profiling.

His recent publications highlight advancements in diagnosing NASH using circulating biomarkers like TREM2 and developing human melanoma models for translational research. Collaborations span clinical, genomic, and proteomic disciplines, reflecting interdisciplinary approaches to liver disease and cancer research.

• Notable Contributions:
  • 2025: Characterization of melanoma models with tumor spheroids
  • 2025: Proteomic insights into MASLD
  • 2024: Drug screening platforms using human liver slices
  • 2024: Pericyte signaling in murine MASH
  • 2023: TREM2 as a non-invasive NASH biomarker

Frederik Tibert Larsen actively engages in translational research, bridging genomic studies with clinical applications in metabolic and oncological diseases.