معرفی
Professor Esther Braselmann is a faculty member at Georgetown University, affiliated with the Interdisciplinary Science and Medical Science and Medicine (ISM) program and the Shared Facilities' Soft Matter Lab. Her research focuses on developing advanced imaging techniques, particularly Fluorescence Lifetime Imaging Microscopy (FLIM), to study RNA dynamics in live cells. Collaborations include hosting visiting students from Fairfield University, where joint efforts explore fluorescent dyes binding riboswitches and RNA visualization tools like the Riboglow platform.
Her work integrates molecular biology, chemistry, and engineering to create tools for observing RNA in complex systems, such as cancer cell protrusions and zebrafish embryos. Notable techniques include multiplexing FLIM for simultaneous RNA tracking and optimizing fluorophore-quencher systems for precise imaging. These innovations advance understanding of RNA localization, splicing, and interactions in live tissues.
Key contributions include the Riboglow-FLIM platform, which enables quantitative visualization of endogenous RNAs and supports studies of mRNA dynamics in multicellular systems. Braselmann’s team also trains students on cutting-edge equipment, such as FLIM microscopy and cell culture protocols. Her research bridges fundamental biology with translational applications in diagnostics and biotechnology.
