معرفی
Erik Danen is Professor of Cancer Drug Target Discovery and Dean of the Graduate School of Science at Leiden University, affiliated with the Leiden Academic Centre for Drug Research (LACDR) in the Division of Drug Discovery & Safety. His research is centered on understanding the mechanisms of cancer metastasis and therapy resistance through innovative experimental models.
His research interests include cancer cell adhesion, migration, signaling, drug resistance, fibrosis, omics, real-time microscopy, therapeutic target identification, tumor angiogenesis, and immunity. He utilizes advanced 2D and 3D tissue culture models, automated real-time confocal microscopy, and high-throughput RNAi/compound screening within the Leiden University Cell Observatory. His work also involves zebrafish xenograft models for in vivo cancer dissemination studies and biophysical investigations of cell behavior developed in collaboration with the Institute of Physics.
Erik Danen has led and contributed to numerous research projects funded by major organizations such as the Dutch Scientific Organization (NWO), the Dutch Cancer Society (KWF), the European Union (FP7), the Netherlands Genomics Initiative, and Leiden University, serving as principal investigator, work package leader, or co-investigator.
- Current PhD Candidates: Cecilia Bergonzini, Klara Beslmüller, Jeremy Broekhuis, Michiel van Dijk, Kim Elbertse
- Former PhD Candidates: Bircan Çoban, Qiuyu Li, Olga Iendaltseva, Zi Wang, Stephan Huveneers
He leads the Cancer Drug Target Discovery group and conducts his research primarily within the Leiden University Cell Observatory. His interdisciplinary collaborations span the Institute of Biology and the Institute of Physics at Leiden University, fostering a highly integrated research environment.
