Eric S Goetzman

Eric S Goetzman, PhD is an Associate Professor of Pediatrics at the University of Pittsburgh School of Medicine in the Division of Genetic and Genomic Medicine. He also holds a secondary appointment in the Department of Genetics at the University of Pittsburgh School of Public Health. His research is based at the UPMC Children's Hospital of Pittsburgh where he maintains an active laboratory investigating metabolism and mitochondrial function. Dr. Goetzman serves as a key faculty member in the Division of Genetic and Genomic Medicine, contributing to both clinical and basic science research programs that focus on genetic disorders.

• BS, Psychology/Pre-Med, University of Minnesota-Morris, 1994
• PhD, Medical Genetics, University of Alabama-Birmingham, 2002
• Postdoctoral Fellowship, Mayo Clinic, 2002-2004
• Postdoctoral Fellowship, UPMC Children's Hospital of Pittsburgh, 2004-2006

Dr. Goetzman's research focuses on metabolism and mitochondrial function, with particular emphasis on fat metabolism and peroxisomal activity. His laboratory investigates how post-translational modifications of metabolic enzymes control their activity and function, which has implications for understanding and treating inborn errors of metabolism. His work has advanced the understanding of alternative dietary fats for therapeutic applications in metabolic disorders. The research spans basic biochemical mechanisms to translational applications, with particular focus on lysine acylation, fatty acid oxidation disorders, and the role of peroxisomes in metabolic health. His laboratory frequently employs mouse models, proteomics, and metabolomics approaches to study metabolic regulation in health and disease.

Analysis of Dr. Goetzman's recent publications reveals a strong focus on metabolic regulation, particularly involving mitochondria and peroxisomes. His research spans multiple organ systems including kidney, liver, heart, and brain, with consistent themes around metabolic regulation in disease states. A significant portion of his recent work investigates therapeutic applications of dicarboxylic acids for metabolic disorders and acute kidney injury. His publications demonstrate interdisciplinary collaboration across nephrology, cardiology, oncology, and ophthalmology, highlighting the systemic nature of metabolic regulation. The research increasingly incorporates sex-specific differences in metabolism and explores the role of sirtuins in metabolic regulation.

• Session Chair, INFORM Meeting, Amsterdam, Netherlands (2019)
• Travel Award, INFORM Meeting, Amsterdam, Netherlands (2019)
• Travel Award, INFORM Meeting, Athens, Greece (2018)
• Best of JBC for 2017, Metabolism Category (2018)
• Faculty Spotlight, University of Pittsburgh Liver Center (2017)

Dr. Goetzman is actively involved in multiple NIH-funded research projects as PI or co-investigator, including R01 grants focused on peroxisomal metabolism, fatty acid oxidation disorders, and acute kidney injury. His laboratory maintains strong collaborations with clinical researchers at UPMC Children's Hospital and the University of Pittsburgh, particularly in the areas of inborn errors of metabolism and metabolic aspects of organ function. He is a member of several research networks including the International Network for Fatty Acid Oxidation Disorders Research and Management and the Pittsburgh Center for Metabolism & Mitochondrial Medicine, which facilitate collaborative research and translation of findings to clinical practice.

Dr. Goetzman's laboratory is part of the Division of Genetic and Genomic Medicine at the UPMC Children's Hospital of Pittsburgh, operating within the Rangos Research Center. His research team includes postdoctoral fellows, graduate students, and research staff working on various aspects of metabolism and mitochondrial function. The laboratory collaborates extensively with other research groups at the University of Pittsburgh, particularly with the Pittsburgh Center for Metabolism & Mitochondrial Medicine and the Pittsburgh Liver Center. These collaborations provide access to specialized equipment and expertise in areas such as metabolomics, proteomics, and mouse model development, supporting a comprehensive approach to studying metabolic regulation in health and disease.