معرفی
Eric S Bennett serves as Professor and Chair of the Department of Neuroscience, Cell Biology, and Physiology at Wright State University's School of Medicine. His research program investigates the critical role of glycosylation in regulating electrical signaling across cardiac, neuronal, and skeletal muscle systems, with direct implications for understanding arrhythmias, cardiomyopathies, and neuromuscular disorders.
Education:
- B.S. in Applied & Engineering Physics from Cornell University
- M.S. in Biophysics from University of Rochester School of Medicine and Dentistry
- Ph.D. in Biophysics from University of Rochester School of Medicine and Dentistry
Dr. Bennett's laboratory focuses on how posttranslational glycosylation modifications alter transmembrane protein function, particularly voltage-gated ion channels, and how these changes impact electromechanical signaling in health and disease. His team employs multidisciplinary approaches spanning molecular biology, electrophysiology, and computational modeling to investigate glycan-dependent mechanisms in cardiac arrhythmogenesis, heart failure, and neuronal excitability disorders. Current projects examine sialylation's role in sodium/potassium channel gating, its contribution to cardiac electromechanical dysfunction, and glycosylation-mediated alterations in neuronal signaling pathways using conditional mouse knockout models.
His publication record demonstrates consistent innovation at the intersection of glycobiology and electrophysiology, with recent work emphasizing computational modeling of glyco-altered cardiac function and mechanistic studies of sialylation in channelopathies. The research portfolio shows increasing integration of in-silico approaches with traditional wet-lab techniques to model cardiac function across multiple physiological scales.
Scientific recognition includes:
- Feature article of the month designation by Functional Glycomics Gateway (Nature.com, 2009)
- Featured Article status in IEEE Journal of Biomedical and Health Informatics
Dr. Bennett maintains active research collaborations, notably with Dr. Hui Yang at Penn State University for mathematical modeling of cardiac systems, and has secured sustained grant funding for investigations into glycosylation's role in ion channel pathophysiology. His laboratory directs comprehensive training programs for graduate students in biophysics and physiology.
The research environment features state-of-the-art facilities for optical mapping of cardiac electrical activity, cellular electrophysiology, protein/glycan biochemistry, and computational modeling, supporting integrated studies from molecular mechanisms to whole-organ function.
