Enni Markkanen

Enni Markkanen is a full Professor of Pharmacotherapy and Toxicology at the Institute of Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University of Zurich. Her research bridges comparative oncology and molecular pathology through translational studies across human, canine, and feline cancer models.

• Focus on cancer-associated stroma mechanisms
• Development of cross-species sarcoma models
• Expertise in laser-capture microdissection and omics analysis

Key research themes include:

• Comparative Oncology: Leveraging natural cancers in pets to understand human tumor biology.
• Stromal Reprogramming: Mechanistic analysis of cancer-stroma interactions using RNAseq and proteomics.
• DNA Damage Response: Investigating BER pathway deficiencies in genetic instability and neuropsychiatric conditions.

Recent publications demonstrate cross-disciplinary impact through:

• Proteomic characterization of canine fibrosarcoma
• Identification of conserved stromal disease drivers
• Development of fluorescence-guided surgical tools
• Molecular mapping of stress response activation

Her work has produced 15 recent publications (2021-2025) spanning Nature Communications, Neoplasia, and Cancers, focusing on:

• Single-species and cross-species tumor comparison
• Stromal reprogramming mechanisms
• DNA damage response pathways
• Translational imaging and therapeutic strategies