معرفی
Eleonore von Castelmur is an Associate Professor and Docent at Linköping University's Department of Physics, Chemistry and Biology (IFM), within the Chemistry (KEMI) division. Her research focuses on structural biology techniques to elucidate molecular mechanisms of protein function in health and disease, particularly in cancer metastasis and viral lifecycle processes. She leads the von Castelmur lab, investigating evolutionary repurposing of human proteins by picornaviruses for antiviral drug development.
Her academic affiliations include the Wallenberg Centre for Molecular Medicine (WCMM) at LiU, which bridges medical technology and bioengineering. Her work spans structural biology, virology, cancer biology, and biophysics, with contributions to understanding protein-protein interactions in diseases like colorectal cancer and SARS-CoV-2 infection mechanisms. She collaborates across disciplines, exemplified by pandemic-era research on immune response analysis and vaccine development.
Key research themes include metastasis regulation via TBX3/Wnt signaling, protein-ligand interactions in transthyretin amyloids, and structural dynamics of enzymes like PLA2G16. Over 18 years, her publications (2007–2025) address topics from titin elasticity in muscles to viral entry mechanisms. She holds no publicly listed scientific awards but contributes to high-impact journals like *Nature*, *Science*, and *PNAS*.
Von Castelmur's lab collaborates with MAX IV and other facilities, focusing on applying structural insights to develop antiviral therapies and understand protein dysfunction in disease. Her interdisciplinary approach integrates computational chemistry, molecular dynamics, and crystallography to solve complex biological questions.
