معرفی
Sofie Nyström is an Associate Professor and Docent at Linköping University's Department of Physics, Chemistry and Biology (IFM), within the Chemistry (KEMI) division. Her research focuses on amyloid proteins, prion diseases, and the interplay between viral proteins and amyloid formation. She investigates structural heterogeneity of amyloids, viral amyloidogenesis, and their roles in neurodegenerative diseases like Alzheimer's.
Key research areas include the molecular mechanisms of amyloid formation, strain-specific effects of prions, and the implications of amyloid polymorphism for diagnostics and treatments. Her work combines protein science tools, in vivo models, and advanced imaging techniques to study amyloid interactions and their pathological consequences. Collaborators include Per Hammarström and Peter Nilsson, with notable contributions to understanding SARS-CoV-2 spike protein amyloidogenesis linked to Long COVID symptoms.
Current projects involve post-doctoral researchers like Debdeep Chatterjee and master students including Vilma Odland, Henrik Westman, and Ebba Hellstrand. Her lab, part of the Hammarström group, explores amyloid behavior in P3-level biosafety conditions, particularly for prion research. Recent studies highlight novel fluorescent probes for amyloid imaging and the role of viral amyloids in disease progression.
Publications emphasize structural insights into amyloid deposits, cross-seeding mechanisms between proteins, and the development of diagnostic tools. Her work bridges fundamental biophysics with clinical applications, addressing urgent questions in neurology and infectious disease.
