معرفی
Dr. Edwin Moore is Professor and Head of the Department of Cellular and Physiological Sciences at the University of British Columbia Faculty of Medicine. His research focuses on excitation-contraction coupling mechanisms in cardiac and smooth muscle cells.
- B.Sc. and M.Sc. in Physiology from the University of Toronto
- Ph.D. in Pharmacology from the Mayo Clinic
Research Interests: Dr. Moore's laboratory investigates the type-2 cardiac ryanodine receptor (RyR2) that regulate cardiac contractile force through calcium release dynamics. His team examines RyR2 position/function in normal and diseased tissue using:
- Transmission electron microscopy
- Electron tomography
- 3D superresolution immunofluorescence
- Transgenic mouse models
- Ca2+ spark/transient analyses
- Biochemical approaches
Scientific Collaborations: The lab collaborates with Dr. Keng Chou (Chemistry Dept.) for dSTORM system development and is part of UBC's Cardiovascular Research Group. Current projects include:
- Investigating RyR2 variants' pathogenicity using iPSC-derived cardiomyocytes
- Studying dynamic RyR2 interactions through post-translational modifications
- Developing novel correlative microscopy techniques
Lab Members: The interdisciplinary team includes Dr. Parisa Asghari (Research Associate), Dr. David Scriven (Research Associate), and Saif Dababneh (MD/PhD student).
