Edward Robert Smith

Edward Robert Smith is a Professor at Harvard Medical School and Vice Chair of the Department of Neurosurgery at Boston Children's Hospital, where he co-directs the Cerebrovascular Surgery and Interventions Center. He specializes in pediatric neurosurgical management of moyamoya disease, cerebral vascular malformations, and brain tumors, with a focus on translational research in vascular biology.

• Education: MD, Columbia University (1996); MBA (unspecified institution); MS in Medical Engineering, MIT (2023)

His research spans molecular mechanisms of angiogenesis and tumorigenesis in the central nervous system. Key areas include non-invasive biomarker development for brain tumors and vascular diseases, and novel therapeutic interventions targeting vascular stability. The Smith Laboratory, supported by NIH funding, investigates urinary biomarkers for monitoring disease progression and treatment efficacy.

Recent publications highlight his work on genetic predispositions to moyamoya (e.g., ANO1 mutations), endovascular techniques for vein of Galen malformations, and perioperative care protocols for pediatric cerebrovascular patients. Collaborations with Dr. Marsha Moses' Vascular Biology Program underscore his interdisciplinary approach.

• Scientific Awards:
  • Regional/national clinical awards
  • Chair, American Society of Pediatric Neurosurgery Ethics Committee
  • President-elect, American Association of Neurologic Surgery Young Neurosurgeons Committee

Smith actively teaches neuroanatomy at Harvard and Tufts, leads national grand rounds, and contributes to clinical guidelines for moyamoya and cerebrovascular disease. His lab's work on biomarker "fingerprints" has influenced international clinical practices and trial designs.