معرفی
Edward Geisinger is an Assistant Professor in the Department of Biology at Northeastern University, affiliated with the College of Science. His research focuses on understanding the molecular mechanisms underlying antibiotic resistance and pathogenesis in Acinetobacter baumannii, a major hospital-acquired pathogen. The Geisinger Lab employs systems biology, molecular genetics, and animal models to study bacterial cell envelope dynamics, regulatory networks, and drug resistance evolution. Key goals include identifying novel targets for antimicrobial therapies.
Research interests center on how A. baumannii adapts to antimicrobial stress through transcriptional regulation (e.g., BfmR), efflux pumps, and cell wall remodeling. The lab also explores phage susceptibility and host-pathogen interactions in immunocompromised hosts. Located in the Mugar Life Sciences Building, the lab collaborates on drug discovery efforts to combat multidrug-resistant infections.
Recent work highlights genomic approaches (e.g., CRISPR interference, transposon mutagenesis) to identify essential genes and fitness determinants. Publications emphasize envelope biology, virulence regulation, and evolutionary pathways of resistance. The lab aims to translate fundamental discoveries into clinical solutions for antibiotic-resistant bacterial infections.
