معرفی
E. James Petersson is a Professor in the Department of Chemistry at the University of Pennsylvania, with affiliations in the Perelman School of Medicine and the Biochemistry and Molecular Biophysics Graduate Group. His research integrates organic synthesis, molecular biology, computational modeling, and biophysics to investigate protein folding, protein-protein interactions, and their roles in diseases such as Parkinson’s and antibiotic resistance.
His research interests center on developing chemical tools to study protein dynamics, particularly through the use of unnatural amino acids, thioamide modifications, and fluorescent probes. His lab focuses on understanding the misfolding of proteins like α-synuclein, the mechanisms of bacterial SOS response in antibiotic resistance, and post-translational modifications such as arginylation and acetylation. These tools enable high-resolution studies of protein conformational changes, aggregation, and signaling pathways.
The recent publications reveal a strong trend toward interdisciplinary approaches, combining synthetic chemistry, biophysics, computational modeling, and neuroscience. His work spans from fundamental protein engineering and probe development to applications in disease modeling and diagnostic imaging, including PET tracers for synucleinopathies. The use of machine learning for predicting amyloidogenesis and advanced FRET techniques for conformational analysis highlights the cutting-edge nature of his research.
He is supported by major funding agencies including the NIH, NSF, and DOE, reflecting the significance and impact of his work. His collaborations span across departments and institutions, particularly in neuroscience and radiology.
Professor Petersson’s lab actively trains students and researchers in chemical biology and biophysics. He contributes to outreach and education through his group’s active presence and participation in scientific communities.
حوزههای پژوهشی
