معرفی
Douglas E Brash is a Senior Research Scientist and Clinical Professor at Yale School of Medicine, with joint appointments in Therapeutic Radiology and Dermatology. His research focuses on the molecular mechanisms of UV-induced DNA damage and its role in skin cancer development.
- BS in Engineering Physics from University of Illinois
- PhD in Biophysics from Ohio State University
- Postdoctoral training at Harvard Medical School and Harvard School of Public Health
Brash's work has established critical links between UV photoproducts (CPDs and (6-4) photoproducts) and mutation patterns in skin cancer genes like p53 and PTCH. His lab discovered that UV damage leads to physiological clonal expansion of mutant keratinocytes, and recently identified 'chemiexcitation' as a novel dark chemical carcinogenic mechanism involving melanin.
Recent publications highlight his work on genomic UV dosimeters, triplet-energy quenching antioxidants, and applications of chemiexcitation in macular degeneration. Collaborations with David Leffell, Ruth Halaban, and others demonstrate interdisciplinary impact.
- Principal Investigator in molecular markers of UV exposure
- Key contributor to Yale SPORE in Skin Cancer
