معرفی
Douglas Alan Marchuk is the James B. Duke Distinguished Professor of Molecular Genetics and Microbiology at Duke University, with additional appointments as Professor of Cell Biology and Director of the Duke University Program in Genetics and Genomics. He is a key member of the Duke Cancer Institute and has led groundbreaking research in vascular malformation genetics.
Dr. Marchuk earned his Ph.D. from the University of Chicago (1985) and has secured major grants from the NIH, Department of Defense, and American Heart Association. His research focuses on the genetic basis of Cerebral Cavernous Malformations (CCM), Hereditary Hemorrhagic Telangiectasia (HHT), and Sturge Weber Syndrome (SWS), revealing critical mechanistic insights into somatic mutations, two-hit pathogenesis, and signaling pathways like TGF-β and RhoA kinase.
His recent publications highlight somatic mutations in GNAQ for SWS, PIK3CA in aggressive CCM, and modifier genes like RABEP2 in stroke outcomes. These studies leverage mouse models and cross-species approaches to validate therapeutic targets.
Dr. Marchuk has received scientific grants from NIH (2015–2025), Department of Defense (2023–2026), and AHA (2022–2025), among others. His lab trains students and researchers in genetic mapping, mouse model development, and translational medicine.
