معرفی
Professor Doryen Bubeck is a structural immunologist at Imperial College London and a satellite group leader at the Francis Crick Institute. She leads a team of 10 researchers focusing on molecular mechanisms of host-pathogen interactions, complement system regulation, and membrane biophysics. Her academic journey includes a B.Sc. from Rensselaer Polytechnic Institute (1999), a Ph.D. in Biophysics from Harvard University (2005), and postdoctoral training at the University of Oxford under EMBO and Cancer Research Institute fellowships. She joined Imperial College London in 2012 as a Lecturer, progressing through Senior Lecturer (2017), Reader (2021), and full Professor (2023). She has held leadership roles as Director of the Centre for Structural Biology (2021–2024) and currently serves as Director of Research for the Department of Life Sciences.
- Education:
- B.Sc. Biochemistry/Biophysics, Rensselaer Polytechnic Institute (1996–1999)
- Ph.D. in Biophysics, Harvard University (1999–2005)
- EMBO Postdoctoral Fellowship, University of Oxford (2005–2010)
- Research Interests: Structural immunology, complement membrane attack complex (MAC), pore-forming toxins, host-pathogen interactions, and membrane biophysics.
Her research has been supported by prestigious grants including the ERC Consolidator Grant, CRUK Career Establishment Award, and Wellcome Trust Investigator Award. Notable achievements include uncovering the 3D structure of the MAC and its inhibition mechanism, as well as elucidating roles of CD59 in immune regulation. She is a Fellow of the Royal Society of Biology and serves on multiple scientific advisory boards.
- Awards:
- GlaxoSmithKline Award (Biochemical Society)
- ERC Consolidator Grant
- CRUK Career Establishment Award
- Fellow of the Royal Society of Biology
Her work bridges structural biology and immunology, with applications in therapeutic design for infectious diseases and cancer. She oversees the Centre for Structural Biology and collaborates widely through Imperial College and the Francis Crick Institute.
