Dongsheng Guo

Dongsheng Guo is an Instructor in the Emerson Lab at UMass Medical School's Department of Neurology, researching human muscle diseases using patient-derived stem cell models. His work focuses on developing stem cell technologies for modeling and treating muscular dystrophies including FSHD, LGMD, and WWS.

Guo developed iMyoblast technology to generate functional muscle stem cells from human induced pluripotent stem cells (hiPSCs). His approach enables advanced disease modeling and therapeutic development for neuromuscular disorders through:

• CRISPR-based gene editing
• Stem cell differentiation protocols
• In vivo functional validation
• Therapeutic screening platforms

Guo earned his PhD from Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, specializing in stem cell modeling of endocrine disorders. His publication record demonstrates progressive contributions to gene editing techniques and stem cell applications for rare diseases. Recent work advances prime editing efficiency and lipid nanoparticle delivery for muscle therapies.