Donald Maurice

Donald Maurice is a Professor in the Department of Biomedical and Molecular Sciences at Queen's University, with cross-appointments at the Translational Institute of Medicine (TIME). His research focuses on cyclic nucleotide signaling pathways, particularly the role of phosphodiesterases (PDEs) in cardiovascular diseases such as atherosclerosis and angiogenesis. He leads the Maurice Lab, investigating how cAMP and cGMP compartmentation regulates vascular cell functions.

Education includes a BSc in Biochemistry (Carleton University, 1985), MSc and PhD in Pharmacology (McMaster University, 1990), and postdoctoral training at the University of North Carolina at Chapel Hill (1993).

Research emphasizes PDEs' spatial regulation in human vascular cells, aiming to develop therapies targeting compartment-specific signaling. His work highlights PDEs' potential in treating maladaptive cardiovascular processes.

Key findings include PDE5's role in platelet function compartmentation and PDE4D's regulation of vascular permeability. Collaborations span translational medicine and drug discovery, with ongoing studies on PDE inhibitors' therapeutic applications.