معرفی
Don Sin is a Professor of Medicine at the University of British Columbia (UBC), Director of the Centre for Heart Lung Innovation (HLI), and a respirologist at St. Paul’s Hospital. He holds a Tier 1 Canada Research Chair and the De Lazzari Family Chair at HLI, with an H-index of 110 from over 700 peer-reviewed publications.
- Education: MD (University of Alberta, 1991), MPH (Harvard University, 1997)
- Leadership: Deputy Chief Editor, European Respiratory Journal; GOLD Scientific Committee member
Research Focus
Dr. Sin specializes in using multi-omics approaches (microbiome, transcriptome, methylome) to study COPD heterogeneity. His work integrates in vivo imaging (CT/MRI) with bronchoscopic sampling to map structural-molecular correlations. Key projects include:
- Phenotyping alveolar macrophages in COPD via single-cell sequencing
- Linking airway dysbiosis to inflammatory responses and hypoxia
- Developing hyperpolarized 129Xe MRI for functional lung imaging
- Testing radiofrequency therapy for emphysema
Scientific Contributions
His recent publications (2025-2023) highlight advances in:
- Epigenetic aging and cannabis smoking effects
- Precision medicine through polygenic/transcriptomic risk scores
- Cardiopulmonary interactions in COPD and Long COVID
Awards & Leadership
Recipient of Canada’s highest research honors, he chairs guideline committees and serves as a principal investigator in national COPD cohorts (e.g., CanCOLD).
