Dominic Gessler

Dominic J. Gessler is an Assistant Professor of Neurological Surgery at UMass Chan Medical School with joint appointments in neuroscience and translational science. His research bridges gene therapy and neuro-oncology.

Dr. Gessler develops AAV-based gene therapies for neurological disorders including Canavan disease, where his work demonstrated restored myelination through metabolic pathway redirection. His clinical research explores GammaTile brachytherapy for glioblastoma treatment. He has engineered novel AAV capsids for optimized CNS delivery.

His publications reflect dual expertise in molecular therapies and clinical neuro-oncology. Recent work advances viral vector design while clinical studies establish safety profiles for surgically-targeted radiation.