Diomedes Logothetis

Diomedes Logothetis is a Professor in the Department of Pharmaceutical Sciences and Affiliated Faculty in Bioengineering at Northeastern University. His research focuses on ion channel physiology, G-protein coupled receptor (GPCR) signaling, and lipid-regulated membrane protein functions. He explores molecular mechanisms underlying ion channel activation, pharmacological modulation, and their implications in neurological and cardiovascular disorders.

Key research themes include:

• GIRK channel regulation by phosphoinositides and G-proteins
• Structural-functional studies of TRP, KCa, and BK channels
• GPCR heteromerization and cross-signaling in neuropsychiatric diseases
• Development of optogenetic tools for kinase signaling studies

Recent work emphasizes:

• Small molecule activators/inhibitors for therapeutic applications
• Role of cholesterol and PIP2 in channel function
• Mechanosensitive ion channel regulation
• Computational modeling of receptor activation pathways

His lab employs advanced techniques including cryo-EM, molecular dynamics simulations, and optogenetic approaches to unravel molecular mechanisms at the lipid-protein interface. Current projects explore novel therapeutic targets for arrhythmias, schizophrenia, and pain management.