معرفی
Desislava M. Doycheva, PhD, is an Assistant Research Professor in the School of Medicine, jointly affiliated with the Cardiology Division (Department of Medicine) and Physiology Division (Department of Basic Sciences). Her research focuses on molecular mechanisms of neuroprotection in neonatal brain injuries, particularly hypoxic-ischemic encephalopathy (HIE) and germinal matrix hemorrhage.
Dr. Doycheva's work explores signaling pathways such as AMPK/Nrf2, microglial polarization, and inflammasome regulation. Her interests include neuroinflammation mitigation, oxidative stress reduction, and developing therapies for stroke and neonatal brain injuries. She utilizes rodent models to investigate pharmacological interventions targeting apoptosis and neurodegeneration.
Her recent publications emphasize neuroprotective strategies in neonatal HIE, cerebral hemorrhage, and ischemic stroke, with consistent themes in molecular pathway modulation (e.g., AMPK/Sirt1, AdipoR1, MC1R) and therapeutic timing. Research trends highlight innovations in immunotherapy, delayed recanalization, and biomarker diagnostics.
Grants & Projects:
- Principal Investigator: 'Novel Therapeutic Strategies for Treatment of Neonatal HIE' (American Heart Association, 2020–2023)
- Post Doctoral Associate: 'Harness Germinal Matrix Hemorrhage' (National Institutes of Health, 2012–2017)
