معرفی
Professor Denise Sheer is a leading Human Geneticist at the Blizard Institute (Faculty of Medicine and Dentistry, Queen Mary University of London). Her research focuses on chromatin architecture, nuclear organization, and the molecular pathology of pediatric brain tumors, particularly low-grade gliomas. She also investigates protein aggregation in neurodegenerative diseases and cancer genetics/epigenetics.
Key affiliations include:
- Centre for Genomics and Child Health
- Member of: Children’s Cancer and Leukaemia Group, British Neuro-Oncology Society, European Society for Paediatric Oncology
Research Themes:
- MAPK and NF-κB pathway dysregulation in pediatric low-grade gliomas
- Microhomology-mediated genomic structural variation
- Role of CTCF/BORIS in nuclear organization
- Epigenetic signatures in brain tumors
- Protein aggregation mechanisms in neurodegeneration
Scientific Awards:
- 2009 - Jeremy Jass Prize for Excellence in Pathology (RAF gene fusion discoveries)
- 2015 - Queen Mary Innovation Proof of Concept Award (protein aggregation in neurodegenerative diseases)
Grants:
- The Brain Tumour Charity
- Rosetrees Trust
- Barts Charity
- Queen Mary Innovation
Advising: Primary supervisor to Lewis Woodward; secondary advisor to Sara Lucchini, Niamh Baker, and Myrianni Constantinou. Collaborates with institutions including the German Cancer Research Centre (DKFZ) and St. Jude Children’s Research Hospital.
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