Declan O'Regan

Declan O'Regan is the British Heart Foundation Chair of Cardiovascular AI and Professor of Imaging Sciences at Imperial College London's Faculty of Medicine. He leads the Computational Cardiac Imaging Group at the MRC Laboratory of Medical Sciences and serves as Director of Imaging Research at Imperial College Healthcare NHS Trust. His research integrates machine learning with cardiovascular imaging, genetics, and environmental data to uncover disease mechanisms and improve predictive medicine. Key affiliations include the BHF Centre of Research Excellence, EPSRC Centre for Maths of Precision Healthcare, and multiple imaging networks.

Education: BSc (University of London), MBBS (University of London), PhD (Imperial College London), and postgraduate training in Radiology (FRCR) and Medicine (FRCP). Professional roles extend to editorial boards of journals like the European Heart Journal–Cardiovascular Imaging and leadership in societies such as the British Society of Cardiac MRI.

Research focuses on AI-driven diagnostics, cardiovascular aging, and genetic risk factors. Notable work includes developing algorithms for predicting survival from cardiac motion and collaborating with industry on drug discovery. Funders include the MRC, BHF, NIH, and pharmaceutical/biotech companies.

Lab activities emphasize translational research, patient collaboration, and open science. His group’s innovations span cardiac motion capture, genotype-phenotype modeling, and AI-enhanced ECG analysis for early disease detection. Current initiatives explore the impacts of environmental factors (e.g., aircraft noise) on cardiovascular health and post-COVID-19 cardiac sequelae.