معرفی
Davide Corinti is a Researcher at the Department of Chemistry and Pharmacy Technology within Sapienza University of Rome. His research focuses on the molecular characterization of metal-based anticancer drugs (e.g., cisplatin, carboplatin) and their interactions with biomolecules using advanced mass spectrometry techniques, particularly IRMPD spectroscopy. He investigates binding motifs, reaction intermediates, and stability factors of platinum complexes, as well as applications in pharmaceutical formulations like nanoemulsions.
- Current research projects include Spectroscopic and computational investigation of structural motifs and deprotonation sites of thyroid hormones
- Elusive intermediates in platinum(IV) prodrug reaction mechanisms
- Competition of binding sites in cisplatin-(thio)uracil interactions
- Protonated curcumin and its metal coordination properties
His work bridges inorganic chemistry, pharmaceutical technology, and bioanalytical methods, with recent publications in journals like Inorganic Chemistry, Journal of Medicinal Chemistry, and ChemMedChem. He teaches General and Inorganic Chemistry and Bioinorganic Chemistry to pharmacy students.
Key scientific contributions include elucidating the gas-phase behavior of platinum drugs, identifying binding sites for nucleophilic attacks, and developing spectroscopic methods for post-translational modification detection. His research integrates experimental mass spectrometry with quantum-chemical simulations to probe molecular reactivity.
Davide Corinti در سایتهای دیگر
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